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两种狒狒内源性病毒株表现出高度的基因保守性。

Two strains of baboon endogenous virus demonstrate a high degree of genetic conservation.

作者信息

Gelmann E P, Josephs S F, Wong-Staal F

出版信息

Gene. 1983 Jan-Feb;21(1-2):161-4. doi: 10.1016/0378-1119(83)90157-9.

Abstract

Molecular clones of the baboon endogenous viruses 455K, from Papio anubis, and M7, from Papio cynocephalus, have been constructed from unintegrated viral DNA. Although two specific restriction sites do distinguish the two, detailed restriction maps are nearly identical and heteroduplex molecules show complete homology. The latter observations indicate that this endogenous retrovirus genome has been strongly conserved among different species of baboon.

摘要

已从未整合的病毒DNA构建了来自东非狒狒的狒狒内源性病毒455K和来自黄狒狒的M7的分子克隆。尽管两个特定的限制性酶切位点确实能区分这两者,但详细的限制性酶切图谱几乎相同,异源双链分子显示出完全同源性。后一项观察结果表明,这种内源性逆转录病毒基因组在不同种类的狒狒中得到了高度保守。

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