Lister T A, Cullen M H, Beard M E, Brearley R L, Whitehouse J M, Wrigley P F, Stansfeld A G, Sutcliffe S B, Malpas J S, Crowther D
Br Med J. 1978 Mar 4;1(6112):533-7. doi: 10.1136/bmj.1.6112.533.
Sixty-six untreated patients with advanced non-Hodgkin's lymphoma of favourable histological type were allocated alternately to initial treatment with cyclophosphamide, vincristine, and prednisolone or with chlorambucil. The complete remission rate was higher in the group receiving combination chemotherapy, but the overall response rate was the same for both groups. The mean duration of complete remission was the same as that of good partial remission, and was the same for both treatments. The duration of remission was influenced by histological type and extent of disease at presentation, but not age. Those who responded to the initial treatment (whether with complete or with good partial remission) survived significantly longer than did non-responders. It is concluded that neither treatment is satisfactory and that new treatment programmes are needed for patients with a favourable prognosis, especially young patients with extensive disease.
66例未经治疗的组织学类型良好的晚期非霍奇金淋巴瘤患者被交替分配接受环磷酰胺、长春新碱和泼尼松或苯丁酸氮芥的初始治疗。接受联合化疗的组完全缓解率更高，但两组的总体缓解率相同。完全缓解的平均持续时间与良好部分缓解的平均持续时间相同，且两种治疗方法的这一持续时间相同。缓解持续时间受组织学类型和就诊时疾病范围的影响，但不受年龄影响。对初始治疗有反应的患者（无论是完全缓解还是良好部分缓解）的存活时间明显长于无反应者。结论是两种治疗方法均不令人满意，对于预后良好的患者，尤其是患有广泛疾病的年轻患者，需要新的治疗方案。
