Tatarov G
Tijdschr Diergeneeskd. 1983 Mar 1;108(5):204-9.
Chemicals are being used increasingly in the preparation of vaccines. Thus, an effective vaccine (MK25) against Aujeszky's Disease showing stable genetic characteristics was produced by having 5 iododesoxyuridine exert its action on a particular strain of virus. 5 Bromo-desoxyuridine also has an inhibitory effect on the synthesis of DNA viruses. The development of a new mutant of Aujeszky's Disease virus using this agent is reported. The resulting mutant, MK35, was found to be biologically stable, non-pathogenic for white mice, rabbits, sheep and piglets and, in addition, produced stable immunity in piglets, sheep and rabbits within four days after injection of this mutant.
化学物质在疫苗制备中的使用越来越多。因此，通过让5-碘脱氧尿苷作用于特定病毒株，制备出了一种针对奥耶斯基氏病的有效疫苗（MK25），其遗传特性稳定。5-溴脱氧尿苷对DNA病毒的合成也有抑制作用。报道了使用该试剂培育奥耶斯基氏病病毒新突变体的情况。所得到的突变体MK35在生物学上是稳定的，对白鼠、兔子、绵羊和仔猪无致病性，此外，在给仔猪、绵羊和兔子注射该突变体后的四天内可产生稳定的免疫力。
