Straub O C
Bundesforschungsanstalt für Viruskrankheiten der Tiere, Tübingen.
Berl Munch Tierarztl Wochenschr. 1990 Jul 1;103(7):225-9.
The effects of an inactivated strain of Aujeszky's disease vaccine in cattle were investigated. It has not been possible to use vaccines licensed for use in pigs successfully in cattle even though cattle develop neutralizing antibodies to these vaccines. The addition of zinc compounds to the vaccines resulted in protection in cattle. The basis for the use of zinc is discussed. A mutant based vaccine was effective following local administration, but was not when administered parenterally. Anti-prostaglandin was not effective either, despite its successful use in sheep when administered with BHV1. The vaccine presents a prospect for immunising dogs and cats, and the addition of zinc compounds to other drugs and inducers is discussed.
研究了一种牛奥耶斯基氏病灭活疫苗株的效果。尽管牛能产生针对猪用许可疫苗的中和抗体，但这些疫苗在牛身上使用并未成功。在疫苗中添加锌化合物可使牛获得保护。文中讨论了使用锌的依据。一种基于突变体的疫苗经局部给药有效，但经胃肠外给药则无效。抗前列腺素也无效，尽管其与牛疱疹病毒1型一起给药时在绵羊身上使用成功。该疫苗为犬猫免疫带来了希望，文中还讨论了在其他药物和诱导剂中添加锌化合物的情况。
