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Human leukocyte interferon subtypes have different antiproliferative and antiviral activities on human cells.

作者信息

Fish E N, Banerjee K, Stebbing N

出版信息

Biochem Biophys Res Commun. 1983 Apr 29;112(2):537-46. doi: 10.1016/0006-291x(83)91498-5.

DOI:10.1016/0006-291x(83)91498-5
PMID:6303322
Abstract

The antigrowth effects of 5 different cloned human leukocyte IFN subtypes (IFN-alpha A, B, C, D, F) and 2 molecular hybrids between them (IFN-alpha AD(Bg1II) and IFN-alpha DA(Bg1II)) were examined on 6 different human cell lines. The results indicate that the interferons sort into two distinct groups: IFN-alpha B, C and F showed comparable antiproliferative activity which was greater than that of IFN-alpha A, D, AD(Bg1II) and DA(Bg1II). The interferons could also be assigned to one of two groups on the basis of their antiviral activity. IFN-alpha A, D and AD(Bg1II) were observed to be more protective than IFN-alpha B, C and F against HSV-2 and EMCV infections, i.e. the relative antiviral efficacies of the cloned IFN subtypes were the reverse of their antiproliferative activities.

摘要

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