Robinson J S, Jones C T, Kingston E J
J Dev Physiol. 1983 Apr;5(2):89-100.
Intrauterine growth retardation in fetal sheep was caused by removal of endometrial caruncles prior to conception. Such fetuses are chronically hypoxaemic and to establish their ability to withstand additional episodes of hypoxia, the effects of administration of 9% O2 to the pregnant ewe was investigated. Fetuses were studied at 135-140 days. During maternal hypoxia the small fetuses showed a greater tendency to further hypoxaemia and acidaemia, but the differences compared with controls were not large. Whilst the initial response to hypoxaemia was a fall in heart rate in the small fetuses, unlike the controls, the heart rate returned to normal within 15 min. Metabolite responses to hypoxia in the small fetuses were less than normal and the changes in plasma insulin concentrations were uncommonly small. In contrast the plasma cortisol and ACTH responses to hypoxia were larger than normal in the small fetus. The results are discussed in relation to the altered physiological state of the growth-retarded fetal sheep.
受孕前切除子宫内膜肉阜可导致胎羊宫内生长受限。此类胎儿长期处于低氧状态，为确定其耐受额外缺氧发作的能力，研究了向怀孕母羊给予9%氧气的效果。在135 - 140天时对胎儿进行研究。在母体缺氧期间，小胎儿出现进一步低氧血症和酸血症的倾向更大，但与对照组相比差异不大。虽然小胎儿对低氧血症的初始反应是心率下降，但与对照组不同的是，其心率在15分钟内恢复正常。小胎儿对缺氧的代谢物反应低于正常水平，血浆胰岛素浓度的变化异常小。相比之下，小胎儿血浆皮质醇和促肾上腺皮质激素对缺氧的反应比正常情况更大。结合生长受限胎羊生理状态的改变对结果进行了讨论。
