Hansen T M, Lerche A, Kassis V, Lorenzen I, Søndergaard J
Scand J Rheumatol. 1983;12(2):85-8. doi: 10.3109/03009748309102890.
20 patients with active rheumatoid arthritis were treated for 12 weeks with the prostaglandin E1 precursors cis-linoleic acid and gamma-linolenic acid in the form of primrose evening oil (Efamol) and the co-factors zinc, ascorbic acid, niacin, and pyridoxin (Efavit). There was a slight fall in skin reactivity to UV light during the treatment, but no effect on plasma or urine concentrations of PGE1, cAMP or cGMP. There was no effect of the treatment on ESR, P-fibrinogen, number of tender joints, number of swollen joints, the duration of morning stiffness, or on the patient's estimation of pain.
20名活动性类风湿关节炎患者接受了12周的治疗，使用的是前列腺素E1前体顺式亚油酸和γ-亚麻酸，它们以月见草油（Efamol）的形式存在，并搭配了锌、抗坏血酸、烟酸和吡哆醇等辅助因子（Efavit）。治疗期间，皮肤对紫外线的反应略有下降，但对血浆或尿液中PGE1、cAMP或cGMP的浓度没有影响。该治疗对红细胞沉降率、纤维蛋白原、压痛关节数、肿胀关节数、晨僵持续时间或患者对疼痛的评估均无影响。
