Ueno H, Imamura M, Kikuchi K
Virchows Arch A Pathol Anat Histopathol. 1983;400(1):31-41. doi: 10.1007/BF00627006.
Seventeen placentas from normal Japanese women, obtained from 15 full term gestations and at 2 earlier gestational periods, were observed by electron microscopy for the presence of type C retrovirus-like particles. Immature free and budding particles were found in 16 placentas including those obtained pre-term. Free virus-like particles were seen in the intercellular spaces and within the lysosomes of syncytiotrophoblasts of the chorionic villi. Forms budding from syncytiotrophoblasts were found in 3 cases. Coincident data with the electron microscopic observations were obtained by immunohistological methods. Specific positive staining with antisera against heterogeneic whole murine leukaemia virus were seen within the cytoplasm of trophoblastic cells both in and along the basal lamina.
对17份来自日本正常女性的胎盘进行了电子显微镜观察，以检测是否存在C型逆转录病毒样颗粒。这些胎盘取自15例足月妊娠以及2例更早孕期的妊娠。在16份胎盘中发现了不成熟的游离和出芽颗粒，包括那些早产胎盘。在绒毛膜绒毛合体滋养层细胞的细胞间隙和溶酶体内可见游离病毒样颗粒。在3例中发现了从合体滋养层细胞出芽的形式。通过免疫组织学方法获得了与电子显微镜观察结果相符的数据。用抗异种全鼠白血病病毒抗血清进行特异性阳性染色，在基膜内和沿基膜的滋养层细胞胞质内均可见。
