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1
Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody.利用单克隆抗体在一些皮肤T细胞淋巴瘤和白血病患者的细胞中检测人类T细胞淋巴瘤病毒p19 。
J Exp Med. 1981 Dec 1;154(6):1957-64. doi: 10.1084/jem.154.6.1957.
2
Monoclonal antibodies reactive with human T cell lymphotropic virusI (HTLVI) p19 internal core protein: cross-reactivity with normal tissues and differential reactivity with HTLV types I and II.与人嗜T细胞病毒I型（HTLV-I）p19内部核心蛋白反应的单克隆抗体：与正常组织的交叉反应以及与HTLV I型和II型的差异反应
J Immunol. 1985 Jul;135(1):247-54.
3
[Human T-cell leukemia (lymphoma) virus (HTLV-I) antibodies in Danish patients with cutaneous T-cell lymphoma].丹麦皮肤T细胞淋巴瘤患者中的人类T细胞白血病（淋巴瘤）病毒（HTLV-I）抗体
Hautarzt. 1986 May;37(5):263-5.
4
Natural antibodies to the structural core protein (p24) of the human T-cell leukemia (lymphoma) retrovirus found in sera of leukemia patients in Japan.在日本白血病患者血清中发现的针对人类T细胞白血病（淋巴瘤）逆转录病毒结构核心蛋白（p24）的天然抗体。
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1653-7. doi: 10.1073/pnas.79.5.1653.
5
Monoclonal antibodies against human T cell leukemia-lymphoma virus (HTLV) p24 internal core protein. Use as diagnostic probes and cellular localization of HTLV.抗人T细胞白血病-淋巴瘤病毒（HTLV）p24内部核心蛋白的单克隆抗体。用作诊断探针及HTLV的细胞定位。
J Exp Med. 1984 Apr 1;159(4):1117-31. doi: 10.1084/jem.159.4.1117.
6
A glycoprotein antigen detected with new monoclonal antibodies on the surface of human lymphocytes infected with human T-cell leukemia virus type-I (HTLV-I).一种用新型单克隆抗体在感染了I型人类T细胞白血病病毒（HTLV-I）的人类淋巴细胞表面检测到的糖蛋白抗原。
Int J Cancer. 1985 Nov 15;36(5):549-55. doi: 10.1002/ijc.2910360506.
7
Atypical adult T-cell leukemia-lymphoma: diverse clinical manifestations of adult T-cell leukemia-lymphoma.非典型成人T细胞白血病-淋巴瘤：成人T细胞白血病-淋巴瘤的多样临床表现
Jpn J Clin Oncol. 1983;13 Suppl 2:165-87.
8
HTLV-positive and -negative T-cell lymphomas. Morphological and immunohistochemical differences between European and HTLV-positive Japanese T-cell lymphomas.人嗜T淋巴细胞病毒阳性和阴性T细胞淋巴瘤。欧洲与日本嗜人T淋巴细胞病毒阳性T细胞淋巴瘤之间的形态学及免疫组化差异
Int J Cancer. 1985 Jan 15;35(1):65-72. doi: 10.1002/ijc.2910350111.
9
Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T cell leukemia.一群日本成人T细胞白血病患者体内针对人类逆转录病毒HTLV的天然抗体。
Science. 1982 Feb 19;215(4535):975-8. doi: 10.1126/science.6760397.
10
Natural antibodies to the human T cell lymphoma virus in patients with cutaneous T cell lymphomas.皮肤T细胞淋巴瘤患者体内针对人类T细胞淋巴瘤病毒的天然抗体。
J Exp Med. 1981 Aug 1;154(2):333-46. doi: 10.1084/jem.154.2.333.

引用本文的文献

1
The discovery of the first human retrovirus: HTLV-1 and HTLV-2.第一种人类逆转录病毒的发现：人类嗜T淋巴细胞病毒1型（HTLV-1）和人类嗜T淋巴细胞病毒2型（HTLV-2）。
Retrovirology. 2005 Mar 2;2:17. doi: 10.1186/1742-4690-2-17.
2
T-cell control by human T-cell leukemia/lymphoma virus type 1.1型人类T细胞白血病/淋巴瘤病毒对T细胞的控制
Int J Hematol. 2003 Nov;78(4):280-96. doi: 10.1007/BF02983552.
3
Protective effect of interferon beta on human T cell leukaemia virus type I infection of CD4+ T cells isolated from human cord blood.β干扰素对从人脐带血分离的CD4 + T细胞感染人T细胞白血病病毒I型的保护作用。
Cancer Immunol Immunother. 1993 Jul;37(2):97-104. doi: 10.1007/BF01517041.
4
Human T-cell leukemia-lymphoma virus (HTLV) is in T but not B lymphocytes from a patient with cutaneous T-cell lymphoma.人类T细胞白血病-淋巴瘤病毒（HTLV）存在于一名皮肤T细胞淋巴瘤患者的T淋巴细胞而非B淋巴细胞中。
Proc Natl Acad Sci U S A. 1982 Sep;79(18):5680-3. doi: 10.1073/pnas.79.18.5680.
5
Monoclonal antibody against human T cell leukemia virus p19 defines a human thymic epithelial antigen acquired during ontogeny.抗人T细胞白血病病毒p19的单克隆抗体可识别一种在个体发育过程中获得的人胸腺上皮抗原。
J Exp Med. 1983 Mar 1;157(3):907-20. doi: 10.1084/jem.157.3.907.
6
Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus.人类T细胞白血病/淋巴瘤病毒对人脐带血T细胞的转化
Proc Natl Acad Sci U S A. 1983 Sep;80(17):5402-6. doi: 10.1073/pnas.80.17.5402.
7
Identification of human T cell leukemia virus in a Japanese patient with adult T cell leukemia and cutaneous lymphomatous vasculitis.在一名患有成人T细胞白血病和皮肤淋巴瘤性血管炎的日本患者中鉴定出人T细胞白血病病毒。
Proc Natl Acad Sci U S A. 1983 Apr;80(7):2054-8. doi: 10.1073/pnas.80.7.2054.
8
Evidence for human T cell lymphoma-leukemia virus infection of family members of human T cell lymphoma-leukemia virus positive T cell leukemia-lymphoma patients.人类T细胞淋巴瘤白血病病毒阳性T细胞白血病-淋巴瘤患者家庭成员感染人类T细胞淋巴瘤白血病病毒的证据。
J Exp Med. 1983 Jan 1;157(1):248-58. doi: 10.1084/jem.157.1.248.
9
A second look at intraepithelial Langerhans cells in mycosis fungoides and related disorders. Ultrastructural study with special reference to Langerhans granules and virus-like particles.蕈样肉芽肿及相关疾病中上皮内朗格汉斯细胞的再观察。超微结构研究，特别提及朗格汉斯颗粒和病毒样颗粒。
Virchows Arch A Pathol Anat Histopathol. 1983;402(1):47-60. doi: 10.1007/BF00695048.
10
Establishment of an etiologic relationship between the human T-cell leukemia/lymphoma virus (HTLV) and adult T-cell leukemia.确定人类T细胞白血病/淋巴瘤病毒（HTLV）与成人T细胞白血病之间的病因关系。
Blut. 1983 Jul;47(1):1-12. doi: 10.1007/BF00321045.

本文引用的文献

1
Natural antibodies to the human T cell lymphoma virus in patients with cutaneous T cell lymphomas.皮肤T细胞淋巴瘤患者体内针对人类T细胞淋巴瘤病毒的天然抗体。
J Exp Med. 1981 Aug 1;154(2):333-46. doi: 10.1084/jem.154.2.333.
2
Immunological properties of a type C retrovirus isolated from cultured human T-lymphoma cells and comparison to other mammalian retroviruses.从培养的人T淋巴瘤细胞中分离出的C型逆转录病毒的免疫学特性及其与其他哺乳动物逆转录病毒的比较。
J Virol. 1981 Jun;38(3):906-15. doi: 10.1128/JVI.38.3.906-915.1981.
3
Characterization and distribution of nucleic acid sequences of a novel type C retrovirus isolated from neoplastic human T lymphocytes.从人类肿瘤性T淋巴细胞中分离出的一种新型C型逆转录病毒核酸序列的特征及分布
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1887-91. doi: 10.1073/pnas.78.3.1887.
4
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.从一名皮肤T细胞淋巴瘤患者的新鲜淋巴细胞和培养淋巴细胞中检测并分离C型逆转录病毒颗粒。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415-9. doi: 10.1073/pnas.77.12.7415.
5
T-cell lines established from human T-lymphocytic neoplasias by direct response to T-cell growth factor.通过对T细胞生长因子的直接反应从人T淋巴细胞瘤形成中建立的T细胞系。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6815-9. doi: 10.1073/pnas.77.11.6815.
6
Characterization of the reverse transcriptase from a new retrovirus (HTLV) produced by a human cutaneous T-cell lymphoma cell line.对一种由人类皮肤T细胞淋巴瘤细胞系产生的新型逆转录病毒（HTLV）的逆转录酶的特性研究。
Virology. 1981 Jul 15;112(1):355-60. doi: 10.1016/0042-6822(81)90642-5.
7
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
8
Fusion between immunoglobulin-secreting and nonsecreting myeloma cell lines.免疫球蛋白分泌型与非分泌型骨髓瘤细胞系之间的融合。
Eur J Immunol. 1976 Apr;6(4):292-5. doi: 10.1002/eji.1830060411.
9
Antibodies to major histocompatibility antigens produced by hybrid cell lines.杂交细胞系产生的针对主要组织相容性抗原的抗体。
Nature. 1977 Apr 7;266(5602):550-2. doi: 10.1038/266550a0.
10
Enhanced induction of growth of B lymphoblasts from fresh human blood by primate type-C retroviruses (gibbon ape leukemia virus and simian sarcoma virus).
Int J Cancer. 1979 Feb;23(2):148-56. doi: 10.1002/ijc.2910230203.

利用单克隆抗体在一些皮肤T细胞淋巴瘤和白血病患者的细胞中检测人类T细胞淋巴瘤病毒p19 。

Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody.

作者信息

Robert-Guroff M, Ruscetti F W, Posner L E, Poiesz B J, Gallo R C

出版信息

J Exp Med. 1981 Dec 1;154(6):1957-64. doi: 10.1084/jem.154.6.1957.

DOI:10.1084/jem.154.6.1957
PMID:6274993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186543/
Abstract

A monoclonal antibody specific for the internal p19 protein of a type-C retrovirus (HTLV) isolated from human neoplastic T cells has been developed. Its specificity has been shown by radioimmune precipitation and by affinity chromatography of iodinated HTLV proteins. By indirect immune fluorescence this antibody recognizes only HTLV-producing cells. Examination of cells from patients with cutaneous T cell lymphomas and leukemias and with other types of lymphomas and leukemias indicated that HTLV p19 expression is rare. The monoclonal antibody will be useful in determining the natural reservoir of HTLV, possibly in a subset of mature T cell neoplasias.

摘要

一种针对从人类肿瘤性T细胞中分离出的C型逆转录病毒（HTLV）内部p19蛋白的单克隆抗体已被研制出来。其特异性已通过放射免疫沉淀法以及碘化HTLV蛋白的亲和层析法得以证明。通过间接免疫荧光法，该抗体仅识别产生HTLV的细胞。对皮肤T细胞淋巴瘤和白血病患者以及其他类型淋巴瘤和白血病患者的细胞进行检测表明，HTLV p19表达罕见。这种单克隆抗体将有助于确定HTLV的天然储存库，可能存在于一部分成熟T细胞肿瘤中。