Schweizer T F, Bekhechi A R, Koellreutter B, Reimann S, Pometta D, Bron B A
Am J Clin Nutr. 1983 Jul;38(1):1-11. doi: 10.1093/ajcn/38.1.1.
The normal diet of six healthy volunteers was supplemented by 21 g of dietary fiber from two different soybean seed fiber preparations, either a nonpurified and never-dried soya pulp A (39% dietary fiber) or a purified soya fiber B (79%), for 3 wk each. Mean daily fecal wet weight was increased by 19 and 38% in the fiber periods A and B as compared to a 2-wk control period (p less than 0.05). Stool frequency and transit time remained unchanged. Fecal fiber increased by 52% only during period B. Fecal calcium, magnesium, and iron were increased (p less than 0.05), mainly after higher intakes during both fiber periods. Excretion of neutral steroids remained unchanged, but their concentration was lowered (p less than 0.05). A 21% increase of fecal bile acids by fiber A was specifically due to deoxycholic acid (+32%, p less than 0.01). Oral glucose tolerance was slightly improved after period B. Neither fiber changed serum triglycerides, but fiber B increased low-density lipoprotein-cholesterol by 19% (p less than 0.01) and low-density lipoprotein-phospholipids by 16% (p less than 0.05). The ratio high-density/low-density lipoprotein-cholesterol, however, did not change significantly. Thus, dietary fibers from soybean do not seem to contribute to the hypocholesterolemic effect of soya. The results of this study also demonstrate that two apparently similar dietary fibers, coming from a single source, can exert distinctly different metabolic effects.
六名健康志愿者的正常饮食中补充了来自两种不同大豆种子纤维制剂的21克膳食纤维，一种是未纯化且从未干燥的大豆浆A（膳食纤维含量39%），另一种是纯化的大豆纤维B（膳食纤维含量79%），每种补充3周。与为期2周的对照期相比，在摄入纤维A和纤维B期间，平均每日粪便湿重分别增加了19%和38%（p<0.05）。排便频率和转运时间保持不变。仅在摄入纤维B期间，粪便纤维增加了52%。粪便中的钙、镁和铁含量增加（p<0.05），主要是在两个摄入纤维期间摄入量较高之后。中性类固醇的排泄量保持不变，但其浓度降低（p<0.05）。纤维A使粪便胆汁酸增加21%，这一增加具体归因于脱氧胆酸（增加32%，p<0.01）。在摄入纤维B之后，口服葡萄糖耐量略有改善。两种纤维均未改变血清甘油三酯，但纤维B使低密度脂蛋白胆固醇增加了19%（p<0.01），低密度脂蛋白磷脂增加了16%（p<0.05）。然而，高密度/低密度脂蛋白胆固醇比值没有显著变化。因此，大豆中的膳食纤维似乎对大豆的降胆固醇作用没有贡献。本研究结果还表明，来自单一来源的两种看似相似的膳食纤维可产生明显不同的代谢效应。
