人免疫干扰素（IFN-γ）基因序列与结构。

Human immune interferon (IFN-gamma) gene sequence and structure.

作者信息

Gray P W, Goeddel D V

出版信息

Basic Life Sci. 1983;25:35-61. doi: 10.1007/978-1-4684-4460-5_4.

Abstract

Human IFN-gamma is encoded by a single gene which, in contrast to the IFN-alpha and IFN-beta genes, contains three introns. This gene has been isolated from a recombinant human-gamma gene library, and the entire gene and 5' and 3' flanking regions have been sequenced. Southern hybridizations failed to show any polymorphism of the gene or its flanking regions. The first intron contains a repetitive element which is unrelated to the Alu family repeat.

摘要

人γ干扰素由单个基因编码，与α干扰素和β干扰素基因不同，该基因含有三个内含子。此基因已从重组人γ基因文库中分离出来，整个基因以及5'和3'侧翼区域均已测序。Southern杂交未能显示该基因及其侧翼区域存在任何多态性。第一个内含子包含一个与Alu家族重复序列无关的重复元件。