一种主要的人类白细胞干扰素基因的DNA序列。
DNA sequence of a major human leukocyte interferon gene.
作者信息
Lawn R M, Gross M, Houck C M, Franke A E, Gray P V, Goeddel D V
出版信息
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5435-9. doi: 10.1073/pnas.78.9.5435.
The gene for human leukocyte interferon alpha 2 (designated either LeIF A or HuIFN-alpha 2) has been isolated from a human genome library. The DNA sequence of this gene demonstrates that it lacks introns. The 3' noncoding sequences of the IFN-alpha 2 gene correspond to two types of IFN-alpha 2 cDNA clones we have isolated that have alternate sites of polyadenylylation. A comparison of seven human IFN-alpha sequences shows that they are homologous in the 5' flanking region and contain identical "TATA box" sequences. The recombinant lambda clone containing the IFN-alpha 2 gene also contains two copies of the "Alu family" repeat sequence.
人类白细胞干扰素α2（命名为LeIF A或HuIFN-α2）的基因已从人类基因组文库中分离出来。该基因的DNA序列表明它没有内含子。IFN-α2基因的3'非编码序列对应于我们分离出的两种类型的IFN-α2 cDNA克隆，它们具有不同的聚腺苷酸化位点。对七个人类IFN-α序列的比较表明，它们在5'侧翼区域是同源的，并且包含相同的“TATA盒”序列。含有IFN-α2基因的重组λ克隆还包含两份“Alu家族”重复序列。
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