Cloyd M W, Hartley J W, Rowe W P
J Exp Med. 1980 Mar 1;151(3):542-52. doi: 10.1084/jem.151.3.542.
Recombinant mink cell focus-inducing (MCF) murine leukemic viruses, as well as ecotropic and xenotropic viruses, were tested for ability to accelerate or cause development of lymphoma in AKR and other strains of mice. Of the three classes of virus isolated from AKR, only the MCF viruses were able to accelerate development of AKR lymphoma. This fully supports the idea that the MCF viruses are the proximal cause of spontaneous AKR lymphoma. MCF lymphomagenicity was strain specific, however, in that AKR MCF viruses did not induce lymphomas in many murine strains; they were moderately lymphomagenic in C3H/Bi mice and in National Institutes of Health Swiss partially congenic for Akv-1 or Akv-2. In contrast, MCF viruses from nonthymic hematopoietic neoplasms of C3H/Fg, BALB/c, or mice partially congenic for ecotropic virus loci (Akv-1, Akv-2, Fgv-1, C58v-1, and C58v-2) were not able to accelerate or cause lymphomia in AKR or any other mouse strain tested, including some of the strains of origin. MCF lymphomagenicity correlated with thymic origin in the virus and with ability to replicate in the thymus.
对重组水貂细胞灶性诱导（MCF）鼠白血病病毒以及嗜亲性病毒和异嗜性病毒进行了测试，以检测它们在AKR和其他品系小鼠中加速或引发淋巴瘤发展的能力。从AKR分离出的三类病毒中，只有MCF病毒能够加速AKR淋巴瘤的发展。这充分支持了MCF病毒是自发性AKR淋巴瘤近端病因的观点。然而，MCF致淋巴瘤性具有品系特异性，因为AKR MCF病毒在许多鼠品系中不诱导淋巴瘤；它们在C3H/Bi小鼠以及国立卫生研究院瑞士小鼠（部分携带Akv-1或Akv-2基因）中具有中等致淋巴瘤性。相比之下，来自C3H/Fg、BALB/c或部分携带嗜亲性病毒基因座（Akv-1、Akv-2、Fgv-1、C58v-1和C58v-2）的非胸腺造血肿瘤的MCF病毒，在AKR或任何其他测试的小鼠品系中都不能加速或引发淋巴瘤，包括一些起源品系。MCF致淋巴瘤性与病毒的胸腺起源以及在胸腺中的复制能力相关。
