Pfeiffer G, Willutzki D, Weder D, Becker B, Radsak K
Arch Virol. 1983;76(2):153-9. doi: 10.1007/BF01311699.
By the use of indirect immunofluorescence it is shown that "early" functions of human cytomegalovirus induce a loss of microtubuli in human foreskin fibroblasts within 12 hours postinfection (p.i.) which persists until about 60 hours p.i. At later times p.i. microtubular structures are eventually reestablished. Following depression during the initial 48 hours p.i. tubulin synthesis in infected cells is significantly enhanced during the initial 48 hours p.i. tubulin synthesis in infected cells is significantly enhanced during the late phase of the infectious cycle suggesting that the mechanisms regulating tubulin synthesis are not impaired.
通过间接免疫荧光法显示，人巨细胞病毒的“早期”功能在感染后12小时（p.i.）内会导致人包皮成纤维细胞中的微管丢失，这种情况一直持续到感染后约60小时p.i.。在感染后期，微管结构最终会重新建立。在感染后最初的48小时内微管蛋白合成受到抑制，而在感染周期的后期，感染细胞中的微管蛋白合成在最初的48小时内显著增强，这表明调节微管蛋白合成的机制并未受损。
