Haddada H, de Vaux Saint Cyr C, Duthu A
Cancer Immunol Immunother. 1983;15(2):96-100. doi: 10.1007/BF00199698.
Hamsters were immunized with repeated and progressive doses of strongly antigenic SV40-transformed cells (ZDCl25) and these animals rejected a tumor graft. According to the in vivo Winn test, spleen cells from such immunized animals could be used to transfer the antitumor immunity and protect naive recipients. To characterize the immune effector cells, different techniques of fractionation were used. In all cases the best protection was obtained by whole cell populations, even after reconstitution. The "T-depleted' fraction was more active than the T cell fraction. As shown by the treatment with specific antisera, part of the active population bore surface IgG. The protective activity could be the result of cooperation between different cell populations, one of which, unknown at present, could be the promotor of the transferred immunity and of the tumor neutralization effect.
用反复递增剂量的强抗原性SV40转化细胞（ZDCl25）对仓鼠进行免疫，这些动物排斥肿瘤移植。根据体内温氏试验，来自此类免疫动物的脾细胞可用于传递抗肿瘤免疫力并保护未免疫的受体。为了鉴定免疫效应细胞，采用了不同的分离技术。在所有情况下，即使在重建后，全细胞群体也能提供最佳保护。“T细胞耗尽”部分比T细胞部分更具活性。用特异性抗血清处理表明，部分活性群体带有表面IgG。保护活性可能是不同细胞群体之间合作的结果，其中之一目前尚不清楚，可能是转移免疫力和肿瘤中和效应的促进者。
