Vickery B H, Goodpasture J C, Bergstrom K, Walker K A, Overstreet J W, Katz D F
Fertil Steril. 1983 Aug;40(2):231-6. doi: 10.1016/s0015-0282(16)47242-0.
The spermatostatic potencies of a new vaginal contraceptive agent, RS-37367, and a standard surfactant compound, nonoxynol-9, have been compared by using ejaculated dog and human spermatozoa. RS-37367 was 25 to 50 times more potent than nonoxynol-9 against dog spermatozoa. Nonparallel concentration-response lines were obtained against human spermatozoa. Concentrations of RS-37367 causing immediate spermatostasis against dog spermatozoa resulted in vesiculation of the plasma and outer acrosomal membranes of spermatozoa; similarly, immediately spermatostatic concentrations of nonoxynol-9 were associated with the previously documented generalized membrane stripping. The activities of both RS-37367 and nonoxynol-9 were affected by the concentration of dog spermatozoa in semen-compound mixtures. Short-term (5-minute) exposure of spermatozoa to concentrations of RS-37367 not immediately spermatostatic resulted in progressive immobilization of spermatozoa. Extensive washing of the spermatozoa was not able to reverse this effect, in contrast to spermatozoa transiently exposed to nonoxynol-9.
通过使用射出的犬类和人类精子，对一种新型阴道避孕剂RS - 37367和一种标准表面活性剂化合物壬苯醇醚-9的精子抑制效力进行了比较。RS - 37367对犬类精子的效力比壬苯醇醚-9高25至50倍。针对人类精子获得了非平行的浓度-反应线。导致犬类精子立即发生精子静止的RS - 37367浓度会导致精子的质膜和顶体外膜出现水泡；同样，壬苯醇醚-9的立即产生精子静止作用的浓度与先前记录的普遍膜剥离有关。RS - 37367和壬苯醇醚-9的活性均受精液-化合物混合物中犬类精子浓度的影响。精子短期（5分钟）暴露于未立即产生精子静止作用的RS - 37367浓度下会导致精子逐渐失去活力。与短暂暴露于壬苯醇醚-9的精子相反，对精子进行大量洗涤无法逆转这种作用。
