Diao X H, Zou S, Quigg J, Kaminski J, Zaneveld L J
Tianjin Family Planning Research Institute, Peoples Republic of China.
Contraception. 1990 Dec;42(6):677-82. doi: 10.1016/0010-7824(90)90008-j.
Alkyloxynol-741 ("agent 741") is used in the People's Republic of China as a substitute for nonoxynol-9 in vaginal contraceptive formulations. However, no studies are available that compare the effectiveness of these agents as vaginal spermicides. For this reason, dissolvable polyvinylalcohol (PVA) films were prepared containing various concentrations of alkyloxynol-741 and nonoxynol-9. Films were also prepared containing chlorhexidine, a potentially new vaginal contraceptive agent. Postcoital vaginal spermicidal studies were performed with the films in the stumptailed macaque (Macaca arctoides). The order of spermicidal potency was: alkyloxynol-741 greater than nonoxynol-9 greater than chlorhexidine. These observations suggest that alkyloxynol-741 can be used instead of nonoxynol-9 in those countries where alkyloxynol-741 is more readily available and can be obtained at a lower cost.
烷基氧乙烯醇-741（“741制剂”）在中华人民共和国被用作阴道避孕制剂中壬苯醇醚-9的替代品。然而，尚无研究比较这些制剂作为阴道杀精剂的有效性。因此，制备了含有不同浓度烷基氧乙烯醇-741和壬苯醇醚-9的可溶解聚乙烯醇（PVA）薄膜。还制备了含有洗必泰（一种潜在的新型阴道避孕剂）的薄膜。在断尾猕猴（Macaca arctoides）身上用这些薄膜进行了性交后阴道杀精研究。杀精效力顺序为：烷基氧乙烯醇-741＞壬苯醇醚-9＞洗必泰。这些观察结果表明，在那些烷基氧乙烯醇-741更容易获得且成本更低的国家，烷基氧乙烯醇-741可替代壬苯醇醚-9使用。
