轮状病毒相关性旅行者腹泻：无症状感染中的中和抗体
Rotavirus-associated traveler's diarrhea: neutralizing antibody in asymptomatic infections.
作者信息
Smith C C, Aurelian L, Santosham M, Sack R B
出版信息
Infect Immun. 1983 Aug;41(2):829-33. doi: 10.1128/iai.41.2.829-833.1983.
Abstract
The sera of patients with traveler's diarrhea were assayed for rotavirus-specific immunoglobulins in enzyme-linked immunosorbent and micro-neutralization assays. The antigenically related simian rotavirus SA-11 was used in both assays. Although similar titers of rotavirus-specific binding immunoglobulin G and A were observed in the sera of both symptomatic and asymptomatic subjects, clinical illness appeared to correlate with the failure to detect increased (greater than or equal to fourfold) titers of neutralizing antibodies in the post- as compared with the pretravel sera.
摘要
采用酶联免疫吸附试验和微量中和试验，检测了旅行者腹泻患者血清中的轮状病毒特异性免疫球蛋白。两种试验均使用了抗原相关的猴轮状病毒SA - 11。虽然在有症状和无症状受试者的血清中观察到轮状病毒特异性结合免疫球蛋白G和A的滴度相似，但临床疾病似乎与旅行后血清中中和抗体滴度未检测到升高（大于或等于四倍）有关，而旅行前血清中中和抗体滴度较高。
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