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1
In vivo regulation of the Escherichia coli araC promoter.大肠杆菌araC启动子的体内调控
J Bacteriol. 1983 Aug;155(2):593-600. doi: 10.1128/jb.155.2.593-600.1983.
2
Regulation of the Escherichia coli L-arabinose operon studied by gel electrophoresis DNA binding assay.通过凝胶电泳DNA结合试验研究大肠杆菌L-阿拉伯糖操纵子的调控
J Mol Biol. 1984 Sep 25;178(3):611-28. doi: 10.1016/0022-2836(84)90241-9.
3
Upstream repression and CRP stimulation of the Escherichia coli L-arabinose operon.大肠杆菌L-阿拉伯糖操纵子的上游抑制和CRP刺激
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Dominance relationships among mutant alleles of regulatory gene araC in the Escherichia coli B/R L-arabinose operon.大肠杆菌B/R L-阿拉伯糖操纵子中调控基因araC突变等位基因之间的显性关系。
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The Escherichia coli L-arabinose operon: binding sites of the regulatory proteins and a mechanism of positive and negative regulation.大肠杆菌L-阿拉伯糖操纵子：调节蛋白的结合位点及正负调控机制
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Alternative DNA loops regulate the arabinose operon in Escherichia coli.替代性DNA环调控大肠杆菌中的阿拉伯糖操纵子。
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Variation of half-site organization and DNA looping by AraC protein.AraC蛋白引起的半位点组织和DNA环化的变化。
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本文引用的文献

1
Identification of araC protein and two-dimensional gels, its in vivo instability and normal level.阿糖胞苷蛋白的鉴定及二维凝胶电泳、其体内不稳定性和正常水平
J Mol Biol. 1981 Jun 15;149(1):133-9. doi: 10.1016/0022-2836(81)90265-5.
2
DNA sequence of the araC regulatory gene from Escherichia coli B/r.来自大肠杆菌B/r的araC调控基因的DNA序列。
Nucleic Acids Res. 1980 Nov 25;8(22):5267-74. doi: 10.1093/nar/8.22.5267.
3
Regulation of the L-arabinose transport operons in Escherichia coli.大肠杆菌中L-阿拉伯糖转运操纵子的调控
J Mol Biol. 1981 Sep 15;151(2):215-27. doi: 10.1016/0022-2836(81)90512-x.
4
Mechanism of araC autoregulation and the domains of two overlapping promoters, Pc and PBAD, in the L-arabinose regulatory region of Escherichia coli.大肠杆菌L-阿拉伯糖调控区域中araC自动调节机制以及两个重叠启动子Pc和PBAD的结构域
Proc Natl Acad Sci U S A. 1981 Feb;78(2):752-6. doi: 10.1073/pnas.78.2.752.
5
The Escherichia coli L-arabinose operon: binding sites of the regulatory proteins and a mechanism of positive and negative regulation.大肠杆菌L-阿拉伯糖操纵子：调节蛋白的结合位点及正负调控机制
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3346-50. doi: 10.1073/pnas.77.6.3346.
6
The L-arabinose operon in Escherichia coli B-r: a genetic demonstration of two functional states of the product of a regulator gene.大肠杆菌B-r中的L-阿拉伯糖操纵子：调节基因产物两种功能状态的遗传学证明。
Proc Natl Acad Sci U S A. 1969 Apr;62(4):1100-7. doi: 10.1073/pnas.62.4.1100.
7
Fine-structure deletion map of the Escherichia coli L-arabinose operon.大肠杆菌L-阿拉伯糖操纵子的精细结构缺失图谱。
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3479-84. doi: 10.1073/pnas.69.11.3479.
8
Regulation of the L-arabinose operon BAD in vitro.体外对L-阿拉伯糖操纵子BAD的调控
J Biol Chem. 1974 May 10;249(9):2946-52.
9
Arabinose C protein: regulation of the arabinose operon in vitro.阿拉伯糖C蛋白：体外阿拉伯糖操纵子的调控
Nat New Biol. 1971 Oct 6;233(40):166-70. doi: 10.1038/newbio233166a0.
10
Hyperinducibility as a result of mutation in structural genes and self-catabolite repression in the ara operon.由于结构基因突变导致的超诱导性以及阿拉伯糖操纵子中的自我分解代谢物阻遏。
J Bacteriol. 1971 Jul;107(1):34-52. doi: 10.1128/jb.107.1.34-52.1971.

大肠杆菌araC启动子的体内调控

In vivo regulation of the Escherichia coli araC promoter.

作者信息

Hahn S, Schleif R

出版信息

J Bacteriol. 1983 Aug;155(2):593-600. doi: 10.1128/jb.155.2.593-600.1983.

DOI:10.1128/jb.155.2.593-600.1983
PMID:6307972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC217727/
Abstract

The ara pC promoter is known to be derepressed about fivefold for 20 to 30 min after the addition of arabinose. This transient derepression was studied by using araC::Mu lac insertions and araC-lacZ gene fusions. In strains containing increased levels of araC protein, the pC promoter became progressively less derepressible, but the ara pBAD promoter remained normally inducible. Repression of pC was reestablished 20 min after induction in araB mutants, but did not occur in arabinose-transport-deficient mutants. Finally, mutant araCc proteins which normally do not repress pC did so in the presence of arabinose.

摘要

已知在添加阿拉伯糖后20至30分钟内，阿拉伯糖操纵子pC启动子的阻遏作用会解除约5倍。通过使用araC::Mu lac插入和araC-lacZ基因融合来研究这种短暂的阻遏解除。在含有增加水平araC蛋白的菌株中，pC启动子的阻遏解除能力逐渐降低，但ara pBAD启动子仍保持正常的诱导性。在araB突变体中，诱导后20分钟pC的阻遏作用得以重建，但在阿拉伯糖转运缺陷型突变体中则不会发生。最后，通常不抑制pC的突变型araCc蛋白在阿拉伯糖存在的情况下会抑制pC。