Yura J, Tsuruga N, Hashimoto T, Kamiya Y, Hayashi S, Murata Y
Jpn J Antibiot. 1986 Sep;39(9):2483-7.
Pharmacokinetics and clinical studies on cefotiam (CTM) in pediatric surgery were performed and the results obtained are summarized below. In neonates without congenital heart disease (CHD), serum levels of CTM were rapidly increased following injection of CTM (20 mg/kg, one shot intravenous administration) and the peak values were found at 15 minutes. Six hours later, CTM almost disappeared from the blood. In the patient with CHD, however, CTM was retained in the serum and the urinary excretion was poor. The CTM was administrated prophylactically to prevent postoperative infections in 10 patients. Eight of 10 had no episodes during postoperative period. Wound infection, however, was found in 2 patients. No clinical and laboratory side effects were caused by CTM.
进行了头孢替安（CTM）在小儿外科的药代动力学和临床研究，所得结果总结如下。在无先天性心脏病（CHD）的新生儿中，注射CTM（20mg/kg，单次静脉给药）后血清CTM水平迅速升高，在15分钟时达到峰值。6小时后，CTM几乎从血液中消失。然而，在患有CHD的患者中，CTM保留在血清中且尿排泄较差。对10例患者预防性使用CTM以预防术后感染。10例中有8例在术后期间无感染发生。然而，有2例患者发生了伤口感染。CTM未引起临床和实验室副作用。
