甲状腺功能亢进症患者血清血管紧张素转换酶升高。

Elevated serum angiotensin-converting enzyme in hyperthyroidism.

作者信息

Silverstein E, Schussler G C, Friedland J

出版信息

Am J Med. 1983 Aug;75(2):233-6. doi: 10.1016/0002-9343(83)91198-1.

Abstract

Serum angiotensin-converting enzyme was elevated in patients with hyperthyroidism (72 +/- 31 nmol/minute/ml, n = 12, p less than 0.001) but not in patients with hypothyroidism (38 +/- 3, n = 3) or thyroiditis (26, n = 1), and was positively correlated in 23 patients with serum thyroxine concentration (r = 0.60, p less than 0.01) and triiodothyronine resin uptake (r = 0.56, p less than 0.01). Triiodothyronine failed to enhance the synthesis of angiotensin-converting enzyme in rabbit alveolar macrophages or in human monocytes in culture, suggesting that the increased serum enzyme is a consequence of an effect other than increased angiotensin-converting enzyme synthesis. Hyperthyroidism should be considered in the evaluation of serum angiotensin-converting enzyme for the diagnosis and management of sarcoidosis.

摘要

甲状腺功能亢进患者的血清血管紧张素转换酶升高（72±31纳摩尔/分钟/毫升，n = 12，p<0.001），但甲状腺功能减退患者（38±3，n = 3）或甲状腺炎患者（26，n = 1）则未升高，并且在23例患者中血清血管紧张素转换酶与血清甲状腺素浓度呈正相关（r = 0.60，p<0.01）以及与三碘甲状腺原氨酸树脂摄取呈正相关（r = 0.56，p<0.01）。三碘甲状腺原氨酸未能增强兔肺泡巨噬细胞或培养的人单核细胞中血管紧张素转换酶的合成，这表明血清酶升高是血管紧张素转换酶合成增加以外的其他作用的结果。在评估血清血管紧张素转换酶以诊断和管理结节病时应考虑甲状腺功能亢进。