血清甲状腺素浓度降低的严重非甲状腺疾病中的血清血管紧张素转换酶

Serum angiotensin-converting enzyme in severe nonthyroidal illnesses associated with low serum thyroxine concentration.

作者信息

Brent G A, Hershman J M, Reed A W, Sastre A, Lieberman J

出版信息

Ann Intern Med. 1984 May;100(5):680-3. doi: 10.7326/0003-4819-100-5-680.

Abstract

We evaluated serum angiotensin-converting enzyme levels as an index of thyroid hormone action in severe systemic illness. Angiotensin-converting enzyme was elevated in hyperthyroid patients (37.3 +/- 3.2 U/mL, p less than 0.01) and depressed in hypothyroid patients (17.9 +/- 1.4 U/mL, p less than 0.05). Compared with normal controls (22.6 +/- 1.6 U/mL), patients in an intensive care unit with free thyroxine index greater than 5.0 had normal angiotensin-converting enzyme levels (19.1 +/- 2.5 U/mL), but patients with a free thyroxine index less than 5.0 had angiotensin-converting enzyme levels significantly lower than the normal and hypothyroid groups (10.7 +/- 1.0 U/mL, p less than 0.05). A group of patients in an intensive care unit with alcoholic liver disease (known to elevate angiotensin-converting enzyme) and a low free thyroxine index had depressed angiotensin-converting enzyme levels (16.9 +/- 1.5 U/mL, p less than 0.01). A strong correlation was seen in the combined groups of all patients studied between levels of angiotensin-converting enzyme and a free thyroxine index (r = 0.70, p less than 0.01) and free T3 index (r = 0.72, p less than 0.01).

摘要

我们评估了血清血管紧张素转换酶水平，以此作为严重全身性疾病中甲状腺激素作用的一项指标。甲状腺功能亢进患者的血管紧张素转换酶水平升高（37.3±3.2 U/mL，p<0.01），而甲状腺功能减退患者的该酶水平降低（17.9±1.4 U/mL，p<0.05）。与正常对照组（22.6±1.6 U/mL）相比，重症监护病房中游离甲状腺素指数大于5.0的患者血管紧张素转换酶水平正常（19.1±2.5 U/mL），但游离甲状腺素指数小于5.0的患者血管紧张素转换酶水平显著低于正常组和甲状腺功能减退组（10.7±1.0 U/mL，p<0.05）。一组患有酒精性肝病（已知会使血管紧张素转换酶升高）且游离甲状腺素指数较低的重症监护病房患者，其血管紧张素转换酶水平降低（16.9±1.5 U/mL，p<0.01）。在所有研究患者的合并组中，血管紧张素转换酶水平与游离甲状腺素指数（r = 0.70，p<0.01）和游离T3指数（r = 0.72，p<0.01）之间存在强相关性。