Burrows C F, Merritt A M
Am J Physiol. 1983 Aug;245(2):G301-6. doi: 10.1152/ajpgi.1983.245.2.G301.
The relations between dietary fiber intake and myoelectric activity of the proximal canine colon were examined in four normal beagles fed four diets of varying fiber content in a randomized block design. The basal diet was a canned, meat-based product to which 3, 6, and 9% by weight of alpha-cellulose was added. Colonic motility was monitored using four bipolar Ag-AgCl electrodes. Two slow-wave frequencies were observed: 1) 18.4 +/- 0.1 cycles/min (cpm) and 2) 5.6 +/- 0.03 cpm. Fiber had no effect on either frequency. Spike activity showed three distinct patterns: 1) short bursts phase locked to slow waves of the 18.4 cpm frequency, 2) short bursts phase locked to slow waves of the 5.6 cpm frequency, and 3) prolonged sequences unrelated to slow waves, lasting from 5 to greater than 60 s and grouped in distinct aborally conducted bursts that occurred at a frequency of 2.9 +/- 0.1/h (SE). Fiber had no effect on the frequency of these bursts, but as fiber intake increased there was a linear decrease in burst duration from 11.4 +/- 0.6 min for the basal diet to 8.2 +/- 0.4 min for the high-fiber diet (P less than 0.001). We conclude that luminal factors influence spike burst activity in the proximal colon, because increments of undigestible fiber reduce burst duration on a dose-related basis.
采用随机区组设计，给4只正常的比格犬喂食4种纤维含量不同的日粮，研究膳食纤维摄入量与犬近端结肠肌电活动之间的关系。基础日粮是一种罐装的、以肉为基础的产品，分别添加了3%、6%和9%（重量）的α-纤维素。使用四个双极银-氯化银电极监测结肠运动。观察到两种慢波频率：1）18.4±0.1次/分钟（cpm）和2）5.6±0.03次/分钟。纤维对这两种频率均无影响。锋电位活动呈现三种不同模式：1）与18.4 cpm频率的慢波锁相的短阵发放，2）与5.6 cpm频率的慢波锁相的短阵发放，3）与慢波无关的持续序列，持续5至60多秒，并成组为明显的向口传导的阵发，其发生频率为2.9±0.1次/小时（标准误）。纤维对这些阵发的频率没有影响，但随着纤维摄入量的增加，阵发持续时间呈线性下降，从基础日粮的11.4±0.6分钟降至高纤维日粮的8.2±0.4分钟（P<0.001）。我们得出结论，管腔因素影响近端结肠的锋电位阵发活动，因为不可消化纤维的增加会以剂量相关的方式减少阵发持续时间。
