胎牛关节软骨细胞上的组胺H2受体。
Histamine H2 receptors on foetal-bovine articular chondrocytes.
作者信息
Taylor D J, Yoffe J R, Woolley D E
出版信息
Biochem J. 1983 May 15;212(2):517-20. doi: 10.1042/bj2120517.
Abstract
The dose-response curve of histamine-induced cyclic AMP elevation in monolayer cultures of primary foetal-bovine articular chondrocytes was displaced to the right by cimetidine. In addition, H2 but not H1 antagonists prevented the histamine-induced cyclic AMP elevation, suggesting histamine activates chondrocyte adenylate cyclase through an H2 receptor.
摘要
在原代胎牛关节软骨细胞单层培养物中，西咪替丁使组胺诱导的环磷酸腺苷（cAMP）升高的剂量反应曲线向右移位。此外，H2拮抗剂而非H1拮抗剂可阻止组胺诱导的cAMP升高，这表明组胺通过H2受体激活软骨细胞腺苷酸环化酶。
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