Van der Auwera P, Meunier-Carpentier F, Klastersky J
Rev Infect Dis. 1983 Jul-Aug;5 Suppl 3:S515-22. doi: 10.1093/clinids/5.supplement_3.s515.
In a prospective, randomized study of staphylococcal infections, 27 patients received oxacillin plus rifampin and 29 received oxacillin alone. Vancomycin was substituted for oxacillin when the pathogen was demonstrated to be resistant to oxacillin in vitro. Infection was cured in 18 (67%) of the 27 patients receiving oxacillin (or vancomycin) plus rifampin and in 12 (41%) of the 29 receiving oxacillin (or vancomycin) alone (P less than .01). The clinical effect of the addition of rifampin to oxacillin (or vancomycin) was beneficial in spite of a rifampin-associated reduction in the bactericidal activity of serum containing high concentrations of oxacillin.
在一项关于葡萄球菌感染的前瞻性随机研究中，27例患者接受了苯唑西林加利福平治疗，29例患者仅接受苯唑西林治疗。当病原体在体外被证明对苯唑西林耐药时，用万古霉素替代苯唑西林。接受苯唑西林（或万古霉素）加rifampin的27例患者中有18例（67%）感染得到治愈，而仅接受苯唑西林（或万古霉素）的29例患者中有12例（41%）感染得到治愈（P小于0.01）。尽管利福平会使含高浓度苯唑西林的血清杀菌活性降低，但将利福平添加到苯唑西林（或万古霉素）中仍具有临床益处。
