Schwartz S E, Starr C, Bachman S, Holtzapple P G
J Lipid Res. 1983 Jun;24(6):746-52.
The effects of fiber ingestion on the incorporation of oleic acid into triglyceride and lecithin, acetate incorporation into cholesterol, and monosaccharide and amino acid transport were determined in rat intestine. Prolonged pectin (10% by weight) ingestion caused a decrease in jejunal and ileal cholesterol synthesis (33% and 52%, respectively). Pectin ingestion reduced cholesterol synthesis by 60% in ileal crypt cells, but did not affect cholesterol synthesis in the jejunal or ileal villus cells or in jejunal crypt cells. Cholesterol synthesis in isolated crypt cells was markedly less than in isolated villus cells. Prolonged ingestion of a fiber-free diet supplemented with either cellulose or pectin (10% and 5% by weight, respectively) decreased jejunal lecithin glucose and leucine absorption but did not affect jejunal triglyceride synthesis.
在大鼠肠道中测定了摄入纤维对油酸掺入甘油三酯和卵磷脂、乙酸掺入胆固醇以及单糖和氨基酸转运的影响。长期摄入果胶（重量比10%）导致空肠和回肠胆固醇合成减少（分别减少33%和52%）。摄入果胶使回肠隐窝细胞中的胆固醇合成减少60%，但不影响空肠或回肠绒毛细胞或空肠隐窝细胞中的胆固醇合成。分离的隐窝细胞中的胆固醇合成明显少于分离的绒毛细胞。长期摄入分别添加纤维素或果胶（重量比分别为10%和5%）的无纤维饮食会降低空肠卵磷脂、葡萄糖和亮氨酸的吸收，但不影响空肠甘油三酯的合成。
