Anderson J R, Field H J
J Neurol Sci. 1983 Aug;60(2):181-95. doi: 10.1016/0022-510x(83)90061-8.
Herpes simplex type 1 virus was inoculated into 3-week-old mice via four different routes; intracerebral, intravenous, intranasal and directly into the sciatic nerve. Virus antigen-containing cells in the central nervous system were identified by both an immunofluorescence and immunoperoxidase method. The portal of entry of virus into the CNS appeared to be the major determinant of distribution of virus antigen. Direct haematogenous seeding of virus into the CNS was not proven. It seems probable that infection was first established in sensory ganglia. Within the CNS, regions of high virus antigen concentration paralleled high cell density suggesting cell to cell spread. Consistent involvement of certain neuron groups may be due to their selective vulnerability. These animal experiments provide some explanation for the patterns of CNS herpetic infection observed in man.
将1型单纯疱疹病毒通过四种不同途径接种到3周龄小鼠体内：脑内、静脉内、鼻内以及直接接种到坐骨神经。通过免疫荧光法和免疫过氧化物酶法鉴定中枢神经系统中含病毒抗原的细胞。病毒进入中枢神经系统的门户似乎是病毒抗原分布的主要决定因素。尚未证实病毒通过血行直接播散进入中枢神经系统。感染似乎很可能首先在感觉神经节中建立。在中枢神经系统内，病毒抗原高浓度区域与高细胞密度区域平行，提示病毒在细胞间传播。某些神经元群体的持续受累可能是由于它们的选择性易损性。这些动物实验为在人类中观察到的中枢神经系统疱疹感染模式提供了一些解释。
