Acycloguanosine treatment of herpesvirus infections in footpads and nervous tissue of normal and immunosuppressed mice.

Treatment of herpes simplex virus type 1 (HSV-1)-infected mice with acycloguanosine resulted in significantly fewer virus isolates from nervous tissues than from tissues of untreated animals. Acycloguanosine also significantly reduced the mean titers of HSV-1 recovered from the footpads of drug-treated animals. The anti-herpetic activity of acycloguanosine was observed in both normal and immunosuppressed mice.