一起轮状病毒相关的新生儿坏死性小肠结肠炎暴发疫情。
An outbreak of rotavirus-associated neonatal necrotizing enterocolitis.
作者信息
Rotbart H A, Levin M J, Yolken R H, Manchester D K, Jantzen J
出版信息
J Pediatr. 1983 Sep;103(3):454-9. doi: 10.1016/s0022-3476(83)80427-2.
Abstract
An outbreak of necrotizing enterocolitis and hemorrhagic gastroenteritis occurred in two nurseries during 25 days in August 1982. Eleven of the 40 patients in these nurseries during that time developed disease (attack rate 27.5%). In seven of the 10 patients with gastrointestinal disease, stool samples tested for human rotavirus were positive by ELISA, whereas in 20 unaffected infants, no stools tested demonstrated HRV (P = 0.0001). Eleven staff members had serologic evidence of recent HRV infection. Comparison of risk factors traditionally associated with the development of NEC between the affected and unaffected infants revealed no significant differences. Rotavirus infection was the only finding that was highly correlated with this epidemic.
摘要
1982年8月的25天里，两家托儿所爆发了坏死性小肠结肠炎和出血性肠胃炎。在此期间，这两家托儿所的40名患者中有11人患病（发病率为27.5%）。在10名患有胃肠道疾病的患者中，有7人的粪便样本经ELISA检测人轮状病毒呈阳性，而在20名未受影响的婴儿中，检测的粪便样本均未显示感染人轮状病毒（P = 0.0001）。11名工作人员有近期感染人轮状病毒的血清学证据。对受影响和未受影响婴儿之间传统上与坏死性小肠结肠炎发病相关的风险因素进行比较，未发现显著差异。轮状病毒感染是与此次疫情高度相关的唯一发现。
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