Zoppi G, Gobio-Casali L, Deganello A, Astolfi R, Saccomani F, Cecchettin M
J Pediatr Gastroenterol Nutr. 1982;1(1):91-5. doi: 10.1097/00005176-198201010-00015.
A commercially available wheat bran preparation has been given to six infants between the ages of 6 and 16 months suffering from constipation not due to metabolic or anatomic causes. In all infants, normal bowel movements reappeared after a month of a diet containing bran. After a month on this diet, we observed the following: a decrease in blood levels of calcium, phosphate, and trace elements; an increase in fecal excretion of biliary salts and cholesterol; and an appearance of predominantly proteolytic fecal flora over the saccharolitic flora. These findings, especially the first one, indicate that bran preparations should be used in infancy with extreme caution because of possible side effect on the patient's nutritional status and growth. If bran is used, blood levels of minerals should be repeatedly checked in order to prevent the appearance of vitamin D-dependent rickets and the depletion of trace elements.
一种市售的麦麸制剂被给予了6名6至16个月大、患有非代谢或解剖学原因引起的便秘的婴儿。在所有婴儿中，在食用含麸皮饮食一个月后，正常排便恢复。在这种饮食一个月后，我们观察到以下情况：血液中钙、磷和微量元素水平下降；粪便中胆汁盐和胆固醇的排泄增加；以及粪便菌群中主要为蛋白水解菌而非糖分解菌。这些发现，尤其是第一个发现，表明由于可能对患者营养状况和生长产生副作用，麦麸制剂在婴儿期应极其谨慎使用。如果使用麦麸，应反复检查矿物质的血液水平，以预防维生素D依赖性佝偻病的出现和微量元素的消耗。
