De Mendonça M, Grichois M L, Dagher G, Garay R, Meyer P
Pflugers Arch. 1983 Jun;398(1):64-8. doi: 10.1007/BF00584715.
Plasma Na+, erythrocyte Na+ content and the activity of Na+ transport systems of red cells were measured in Wistar rat fed a normal or high Na+ diet. Net Na+ and K+ fluxes of erythrocytes were also measured in the presence of plasma of rats fed with excess Na+. Na+-K+ cotransport and passive Na+ permeability were increased. Erythrocyte Na+ content was increased after 2 months but not after 8 days of high Na+ intake. No significant difference in plasma Na+ and pump activity could be detected after such a diet. No factor acting in Na+ extrusion was found to be present in plasma of salt loaded rats. These results indicate that Na+ intake may modulate Na+ transport systems, namely passive permeability and Na+-K+ cotransport and that increased Na+ erythrocyte content is not a causative factor.
在喂食正常或高钠饮食的Wistar大鼠中，测量了血浆钠、红细胞钠含量以及红细胞钠转运系统的活性。在喂食过量钠的大鼠血浆存在的情况下，还测量了红细胞的净钠和钾通量。钠钾协同转运和被动钠通透性增加。高钠摄入2个月后红细胞钠含量增加，但8天后未增加。食用这种饮食后，血浆钠和泵活性未检测到显著差异。在盐负荷大鼠的血浆中未发现作用于钠排泄的因素。这些结果表明，钠摄入可能调节钠转运系统，即被动通透性和钠钾协同转运，并且红细胞钠含量增加不是一个致病因素。
