Tomonaga M
Acta Neuropathol. 1983;60(3-4):309-13. doi: 10.1007/BF00691883.
Thirty-three rectus superior extraocular muscles from 23 autopsy cases, all over 60 years, were examined. Eosinophilic inclusions (Hirano bodies) were observed in all the muscles; they were stained deep red by Masson's trichrome stain and were positive for protein stain. They consisted of a collection of filamentous structures of two types: (1) a regular array of filaments 100 A in diameter which sometimes were arrayed in perpendicular planes and (2) another type in a herring bone or ladder-like pattern. Both structures were closely associated with the accumulated thin filaments 50-60 A in diameter (actin?) in the subsarcolemma. The frequent appearance in aged muscle fibers of Hirano bodies indicates that their formation is a change closely related with aging.
对来自23例尸检病例的33条眼外直肌进行了检查，所有病例年龄均超过60岁。在所有肌肉中均观察到嗜酸性包涵体（ Hirano小体）；它们经Masson三色染色呈深红色，蛋白质染色呈阳性。它们由两种丝状结构组成：（1）直径为100埃的规则排列的细丝，有时排列在垂直平面上；（2）另一种呈人字形或梯状图案。这两种结构都与肌膜下直径为50 - 60埃的积聚细丝（肌动蛋白？）密切相关。Hirano小体在老年肌纤维中频繁出现表明它们的形成是与衰老密切相关的一种变化。
