Savastano M, Raffael C, De Franchis G, Andreoli C
ENT Clinic, Padua University, Italy.
Eur Arch Otorhinolaryngol. 1994;251(5):275-7. doi: 10.1007/BF00181884.
The purpose of the present study was to determine the validity of antigen non-specific immunological tests in order to develop a risk-clinical profile of patients with immune-mediated inner ear pathology. The study was carried out on 38 patients with progressive sensorineural hearing loss and a control group of 26 subjects. Serological testing was used to determine cell activation complexes. In patients with hearing loss, T-lymphocyte subpopulations were found to have an increase in cytotoxic T-cells when compared to T-helper, but only for interleukin-2 receptor expression. This difference was significant between patients and the control group. Present findings suggest that T-lymphocyte "early" marker is of particular interest for developing a risk-clinical profile of patients with sensorineural progressive hearing loss of immune origin.
本研究的目的是确定抗原非特异性免疫测试的有效性，以便建立免疫介导性内耳病变患者的风险临床特征。该研究对38例进行性感音神经性听力损失患者和26名受试者组成的对照组进行。采用血清学检测来确定细胞活化复合物。在听力损失患者中，与辅助性T细胞相比，发现细胞毒性T细胞的T淋巴细胞亚群增加，但仅针对白细胞介素-2受体表达。患者与对照组之间的这种差异具有显著性。目前的研究结果表明，T淋巴细胞“早期”标志物对于建立免疫源性进行性感音神经性听力损失患者的风险临床特征特别有意义。
