在寻找DNA变异体过程中优化限制酶的选择。
Optimizing selection of restriction enzymes in the search for DNA variants.
作者信息
Wijsman E M
出版信息
Nucleic Acids Res. 1984 Dec 11;12(23):9209-26. doi: 10.1093/nar/12.23.9209.
Abstract
A model is developed for predicting the relative efficiencies of different enzymes for detecting DNA variants when such variants are the result of single base-pair changes. 71 enzymes are analyzed for this ability in human DNA. Their relative ranked efficiencies are influenced by the sizes of the probes used, and the size of the smallest detectable fragment produced.
摘要
开发了一种模型，用于预测当DNA变异是单碱基对变化的结果时，不同酶检测DNA变异的相对效率。对71种酶在人类DNA中的这种能力进行了分析。它们相对排序的效率受所用探针大小以及产生的最小可检测片段大小的影响。
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