Vignale R A, Lasalvia E, Espasandín J, Borras A
Med Cutan Ibero Lat Am. 1983;11(4):241-6.
The epidermic chalone receptor of skin with lesion and without lesion are studied on 20 patients with active psoriasis. The testlest were performed before and two month after oral treatment with RO 10-9359. Roche. The results show significant variation with an increased a the number of receptors after treatment. As these receptors are in the cell membrane, the authors consider that RO 10-9359 action in on the membrane and its surrounding, making in possible to the epithelial cell to begin its autoregulation, autocontrol and differentiation when the specific activity of the chalones become normal.
对20例活动期银屑病患者有皮损和无皮损皮肤的表皮抑素受体进行了研究。在口服罗氏公司的RO 10 - 9359治疗前及治疗两个月后进行了检测。结果显示有显著变化，治疗后受体数量增加。由于这些受体存在于细胞膜中，作者认为RO 10 - 9359作用于细胞膜及其周围，当抑素的比活性恢复正常时，使上皮细胞能够开始其自身调节、自控和分化。
