温石棉共同暴露对正常人成纤维细胞中苯并[a]芘结合的影响。
Effects of chrysotile co-exposure on BaP binding in normal human fibroblasts.
作者信息
Chang M J, Singh N P, Hart R W
出版信息
Environ Health Perspect. 1983 Sep;51:241-4. doi: 10.1289/ehp.8351241.
Abstract
The effects of chrysotile and benzo(a)pyrene (BaP) co-exposure on uptake, metabolism and BaP binding to nucleic acids were investigated in normal human fibroblasts. A significant enhancement in these parameters was found when co-exposure was carried out under serum-free conditions. In the presence of serum, only a slight enhancement of BaP uptake was detected, while metabolism and binding to nucleic acids were not affected over the 8-hr incubation period studied.
摘要
在正常人成纤维细胞中研究了温石棉和苯并(a)芘（BaP）共同暴露对BaP摄取、代谢及与核酸结合的影响。当在无血清条件下进行共同暴露时，发现这些参数有显著增强。在有血清存在的情况下，仅检测到BaP摄取略有增强，而在研究的8小时孵育期内，代谢及与核酸的结合未受影响。
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