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EMBO J. 1983;2(5):649-55. doi: 10.1002/j.1460-2075.1983.tb01479.x.
2
The effect of anti-Z-DNA antibodies on the B-DNA-Z-DNA equilibrium.抗Z-DNA抗体对B-DNA-Z-DNA平衡的影响。
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本文引用的文献

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The high salt form of poly(dG-dC).poly(dG-dC) is left-handed Z-DNA: Raman spectra of crystals and solutions.聚（dG-dC）·聚（dG-dC）的高盐形式是左手Z-DNA：晶体和溶液的拉曼光谱。
Nucleic Acids Res. 1981 Oct 24;9(20):5443-57. doi: 10.1093/nar/9.20.5443.
2
Mn2+ and other transition metals at low concentration induce the right-to-left helical transformation of poly[d(G-C)].低浓度的锰离子（Mn2+）和其他过渡金属会诱导聚[d(G-C)]从右向左的螺旋转变。
EMBO J. 1982;1(7):777-82. doi: 10.1002/j.1460-2075.1982.tb01247.x.
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Negatively supercoiled plasmids contain left-handed Z-DNA segments as detected by specific antibody binding.通过特异性抗体结合检测发现，负超螺旋质粒含有左手Z-DNA片段。
Cell. 1982 Dec;31(2 Pt 1):309-18. doi: 10.1016/0092-8674(82)90124-6.
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High magnesium content of Escherichia coli B.
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Flipping of cloned d(pCpG)n.d(pCpG)n DNA sequences from right- to left-handed helical structure by salt, Co(III), or negative supercoiling.通过盐、钴（III）或负超螺旋使克隆的d(pCpG)n.d(pCpG)n DNA序列从右手螺旋结构转变为左手螺旋结构。
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4560-4. doi: 10.1073/pnas.79.15.4560.
6
Antibodies specific for left-handed Z-DNA.对左手Z-DNA具有特异性的抗体。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3546-50. doi: 10.1073/pnas.78.6.3546.
7
Antibodies to left-handed Z-DNA bind to interband regions of Drosophila polytene chromosomes.抗左旋Z-DNA的抗体与果蝇多线染色体的间带区域结合。
Nature. 1981 Dec 3;294(5840):417-22. doi: 10.1038/294417a0.
8
Isolation of Drosophila proteins that bind selectively to left-handed Z-DNA.果蝇中选择性结合左旋Z-DNA的蛋白质的分离。
Proc Natl Acad Sci U S A. 1982 Dec;79(24):7729-33. doi: 10.1073/pnas.79.24.7729.
9
Left-handed Z-DNA is induced by supercoiling in physiological ionic conditions.在生理离子条件下，超螺旋可诱导左手Z-DNA的形成。
Nature. 1982 Sep 23;299(5881):312-6. doi: 10.1038/299312a0.
10
Effects of methylation on a synthetic polynucleotide: the B--Z transition in poly(dG-m5dC).poly(dG-m5dC).甲基化对合成多核苷酸的影响：聚（dG-m5dC）·聚（dG-m5dC）中的B-Z转变
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1619-23. doi: 10.1073/pnas.78.3.1619.

负超螺旋质粒中Z-DNA的形成对生理范围内盐浓度的微小变化敏感。

Formation of Z-DNA in negatively supercoiled plasmids is sensitive to small changes in salt concentration within the physiological range.

作者信息

Azorin F, Nordheim A, Rich A

出版信息

EMBO J. 1983;2(5):649-55. doi: 10.1002/j.1460-2075.1983.tb01479.x.

DOI:10.1002/j.1460-2075.1983.tb01479.x
PMID:6315414
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC555164/
Abstract

Negative supercoiling of the plasmid pBR322 with or without an insert of (dG-dC)n induces the formation of Z-DNA as measured by the binding of antibodies specific for Z-DNA. Increasing the concentration of Na+ (or K+) is shown to inhibit the B to Z-DNA conversion. This may be due to the effect of the cation on the B-Z junction. Using the data for B to Z-DNA conversion of the (dG-dC)n inserts, we have estimated the free energy change per base pair as well as the energy of the B-Z junction. In pBR322, a 14-bp segment [CACGGGTGCGCATG] is believed to form Z-DNA at bacterial negative superhelical densities under salt conditions which are similar to those found in vivo.

摘要

无论有无(dG-dC)n插入片段，质粒pBR322的负超螺旋都会诱导Z-DNA的形成，这可通过Z-DNA特异性抗体的结合来测定。结果表明，增加Na+（或K+）浓度可抑制B-DNA向Z-DNA的转变。这可能是由于阳离子对B-Z连接处的影响。利用(dG-dC)n插入片段从B-DNA向Z-DNA转变的数据，我们估算了每个碱基对的自由能变化以及B-Z连接处的能量。在pBR322中，一个14个碱基对的片段[CACGGGTGCGCATG]被认为在类似于体内发现的盐条件下，于细菌负超螺旋密度时形成Z-DNA。