产气荚膜梭菌ε毒素对大鼠心血管系统的影响。
Effect of Clostridium perfringens epsilon toxin on the cardiovascular system of rats.
作者信息
Sakurai J, Nagahama M, Fujii Y
出版信息
Infect Immun. 1983 Dec;42(3):1183-6. doi: 10.1128/iai.42.3.1183-1186.1983.
Abstract
Pressor activity was demonstrated by the intravenous injection of purified epsilon toxin of Clostridium perfringens type D but not by that of epsilon prototoxin. The activity was completely abolished by C. perfringens type B or D antiserum, but not by type A, C, or E antiserum. The rise in blood pressure caused by the toxin was accompanied by a decrease in the blood flow in skin without any change of heart rate and electrocardiogram readings. These results indicate that epsilon toxin possesses pressor activity as well as lethal and dermonecrotic activities.
摘要
通过静脉注射产气荚膜梭菌D型纯化ε毒素可证明其升压活性，而注射ε原毒素则无此活性。该活性可被B型或D型产气荚膜梭菌抗血清完全消除，但不能被A型、C型或E型抗血清消除。毒素引起的血压升高伴随着皮肤血流减少，而心率和心电图读数无任何变化。这些结果表明，ε毒素具有升压活性以及致死和皮肤坏死活性。
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