产气荚膜梭菌α毒素对大鼠心血管系统的影响。

Effect of Clostridium perfringens alpha toxin on the cardiovascular system of rats.

作者信息

Sakurai J, Oshita Y, Fujii Y

出版信息

Toxicon. 1985;23(6):903-12.

Abstract

Clostridium perfringens alpha toxin decreased heart rate, then elevated blood pressure, and finally caused some changes of electrocardiogram readings. The toxin decreased peripheral blood flow before blood pressure started to increase and the blood flow continued to decrease, without any affect on electrocardiogram readings, until the maximal pressure rise caused by the toxin. The toxin caused a rise in blood pressure in a dose-dependent manner. On the other hand, anti-alpha toxin antiserum inhibited both phospholipase C activity and pressor activity. When the toxin was pretreated with cysteine, calcium disodium ethylenediamine tetraacetate and calcium trisodium ethylenetriamine pentaacetate, pressor activity decreased, as well as phospholipase C activity. The results indicate that alpha toxin possesses pressor activity as well as phospholipase C activity.

摘要

产气荚膜梭菌α毒素先降低心率，然后升高血压，最终导致心电图读数出现一些变化。在血压开始升高之前，该毒素会降低外周血流，并且在毒素引起最大压力升高之前，血流持续减少，而对心电图读数没有任何影响。该毒素以剂量依赖的方式引起血压升高。另一方面，抗α毒素抗血清可抑制磷脂酶C活性和升压活性。当毒素用半胱氨酸、乙二胺四乙酸二钠钙和乙三胺五乙酸三钠钙预处理时，升压活性以及磷脂酶C活性均降低。结果表明，α毒素具有升压活性以及磷脂酶C活性。