Stanbridge C M, Butler E B
Int J Gynecol Pathol. 1983;2(3):264-74. doi: 10.1097/00004347-198303000-00004.
Fifty-four patients with multiple condylomatous lesions and/or multicentric neoplasia were identified in a consecutive series of 2,627 colposcopic examinations (2%). Forty-one percent presented with condylomata only and 57% exhibited associated intraepithelial or invasive neoplasia in at least one site. Only one patient was found to have multicentric neoplasia with no condylomatous features. There was a significant increase in mean age between patients presenting with multiple condylomatous lesions and those who had intraepithelial neoplasia as well. An association with pregnancy was found in 17% of the cases, and with renal transplant in 5%. Virus particles compatible with human papillomavirus were found in 62% of the cases examined. Evidence for a causative role in the development of neoplasia of the lower female genital tract is considered.
在连续2627例阴道镜检查中，确诊了54例患有多发性湿疣病变和/或多中心肿瘤的患者（占2%）。41%的患者仅表现为湿疣，57%的患者至少在一个部位伴有上皮内或浸润性肿瘤。仅发现1例患者有多中心肿瘤但无湿疣特征。出现多发性湿疣病变的患者与同时患有上皮内肿瘤的患者相比，平均年龄有显著增加。17%的病例与妊娠有关，5%的病例与肾移植有关。在62%的检查病例中发现了与人乳头瘤病毒相符的病毒颗粒。文中考虑了其在女性下生殖道肿瘤发生中致病作用的证据。
