Gerdes J C, Smith D S
J Gen Virol. 1983 Nov;64 (Pt 11):2441-54. doi: 10.1099/0022-1317-64-11-2441.
Distinct high frequency recurrence (HFRc) or low frequency recurrence (LFRc) phenotypes were observed following rabbit keratitis with three type 1 and five type 2 herpes simplex virus strains. LFRc strains were found to have latently infected the animal but were detected very rarely, if at all, in the eye following the acute phase. The recurrence phenotypes defined in singly infected animals remained unchanged following bilateral infection of the same animal with strains of opposite phenotype. Cocultivation of virus from bilaterally infected animals showed that both virus strains were capable of latently infecting the same animal. Restriction enzyme analysis of plaque-purified virus revealed that some ganglia were latently infected with both parental strains. Recombinants were also found. Some latently infected animals could be re-infected acutely. However, establishment of latency by the superinfecting strain was inhibited.
用三株1型和五株2型单纯疱疹病毒感染兔角膜炎后，观察到了明显的高频复发（HFRc）或低频复发（LFRc）表型。发现LFRc毒株能使动物发生潜伏感染，但在急性期过后，在眼中极少被检测到（如果能检测到的话）。在同一动物被相反表型的毒株双侧感染后，单感染动物中定义的复发表型保持不变。从双侧感染动物中进行病毒共培养表明，两种病毒毒株都能够潜伏感染同一动物。对蚀斑纯化病毒的限制性内切酶分析显示，一些神经节被两种亲本毒株潜伏感染。还发现了重组体。一些潜伏感染的动物可能会被急性再感染。然而，超感染毒株建立潜伏感染受到抑制。
