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编码人视黄醇结合蛋白的全长cDNA的克隆与测序

Cloning and sequencing of a full length cDNA coding for human retinol-binding protein.

作者信息

Colantuoni V, Romano V, Bensi G, Santoro C, Costanzo F, Raugei G, Cortese R

出版信息

Nucleic Acids Res. 1983 Nov 25;11(22):7769-76. doi: 10.1093/nar/11.22.7769.

DOI:10.1093/nar/11.22.7769
PMID:6316270
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC326530/
Abstract

We have isolated and sequenced a cDNA clone coding for human Retinol Binding Protein. The sequence indicates that Retinol Binding Protein is synthesized as a single polypeptide chain precursor which is then matured to the secreted protein by removal of a leader peptide. Southern and Northern blot analysis suggest that the gene is present in one or few copies per haploid genome and is transcribed in a single mRNA species.

摘要

我们已经分离并测序了一个编码人视黄醇结合蛋白的cDNA克隆。序列表明，视黄醇结合蛋白最初作为单条多肽链前体合成，随后通过去除前导肽成熟为分泌蛋白。Southern和Northern印迹分析表明，该基因在单倍体基因组中以单拷贝或少数拷贝存在，并转录为单一的mRNA种类。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1af/326530/7a000a19146a/nar00367-0123-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1af/326530/643d67913a48/nar00367-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1af/326530/7a000a19146a/nar00367-0123-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1af/326530/643d67913a48/nar00367-0122-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1af/326530/7a000a19146a/nar00367-0123-a.jpg

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本文引用的文献

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EMBO J. 1983;2(1):57-61. doi: 10.1002/j.1460-2075.1983.tb01380.x.
2
Effect of retinol status on retinol-binding protein biosynthesis rate and translatable messenger RNA level in rat liver.视黄醇状态对大鼠肝脏中视黄醇结合蛋白生物合成速率及可翻译信使核糖核酸水平的影响。
J Biol Chem. 1982 Jul 10;257(13):7693-7.
3
Biosynthesis of plasma retinol-binding protein in liver as a larger molecular weight precursor.血浆视黄醇结合蛋白在肝脏中作为一种更大分子量前体的生物合成。
视黄醇结合蛋白 4 与 2 型糖尿病：从胰岛素抵抗到胰岛β细胞功能。
Endocrine. 2024 Sep;85(3):1020-1034. doi: 10.1007/s12020-024-03777-5. Epub 2024 Mar 23.
4
Preoperative sarcopenia combined with prognostic nutritional index predicts long-term prognosis of radical gastrectomy with advanced gastric cancer: a comprehensive analysis of two-center study.术前肌少症合并预后营养指数预测进展期胃癌根治术后的长期预后：来自两项中心研究的综合分析。
BMC Cancer. 2023 Aug 14;23(1):751. doi: 10.1186/s12885-023-11251-0.
5
Associations of persistent organic pollutants in human adipose tissue with retinoid levels and their relevance to the redox microenvironment.人体脂肪组织中持久性有机污染物与类视黄醇水平的关联及其与氧化还原微环境的相关性。
Environ Res. 2021 Apr;195:110764. doi: 10.1016/j.envres.2021.110764. Epub 2021 Jan 23.
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Elevated Serum Levels of Retinol-Binding Protein 4 Are Associated with Breast Cancer Risk: A Case-Control Study.血清视黄醇结合蛋白4水平升高与乳腺癌风险相关：一项病例对照研究。
PLoS One. 2016 Dec 21;11(12):e0167498. doi: 10.1371/journal.pone.0167498. eCollection 2016.
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J Cell Biol. 1983 Mar;96(3):907-10. doi: 10.1083/jcb.96.3.907.