Wyman J B, Heaton K W, Manning A P, Wicks A C
Gut. 1978 Feb;19(2):146-50. doi: 10.1136/gut.19.2.146.
Twenty healthy subjects eating normal diets made repeated five-day stool collections, the 10 females making their collections in four to six successive weeks. In most subjects there were striking variations in transit time, measured by Hinton's method. The variability of average faecal wet and dry weight, faecal volume, and the frequency of defaecation was equally great, suggesting that the transit time variations were genuine. The size of individual stools varied even more, often tenfold or more. Faecal water content was relatively constant. There were no significant differences between males and females, and in the females there were no obvious changes related to the phases of the menstrual cycle. The normal variability of colonic function should be taken into account in planning experiments and in interpreting existing data.
20名正常饮食的健康受试者进行了多次为期5天的粪便收集，10名女性在连续4至6周内进行收集。采用辛顿法测量，大多数受试者的转运时间存在显著差异。粪便平均湿重和干重、粪便体积以及排便频率的变异性同样很大，这表明转运时间的差异是真实存在的。个体粪便的大小差异更大，常常相差10倍或更多。粪便含水量相对恒定。男性和女性之间没有显著差异，女性中也没有与月经周期各阶段相关的明显变化。在规划实验和解释现有数据时，应考虑到结肠功能的正常变异性。
