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Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene.人类主要组织相容性抗原DCβ基因的外显子-内含子结构及完整核苷酸序列
Proc Natl Acad Sci U S A. 1983 Dec;80(23):7313-7. doi: 10.1073/pnas.80.23.7313.
2
Class II genes of the human major histocompatibility complex. Comparisons of the DQ and DX alpha and beta genes.人类主要组织相容性复合体的II类基因。DQ和DXα及β基因的比较。
J Biol Chem. 1987 Jun 25;262(18):8767-77.
3
Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes.人类主要组织相容性复合体HLA - SB区域的分子组织及两个SBβ链基因的证据
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Structure and nucleotide sequence of the heavy chain gene of HLA-DR.HLA-DR重链基因的结构与核苷酸序列
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Both alpha and beta chains of HLA-DC class II histocompatibility antigens display extensive polymorphism in their amino-terminal domains.HLA-DC Ⅱ类组织相容性抗原的α链和β链在其氨基末端结构域均表现出广泛的多态性。
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10
Analysis of the distribution of charged residues in the N-terminal region of signal sequences: implications for protein export in prokaryotic and eukaryotic cells.信号序列N端区域带电残基分布分析：对原核细胞和真核细胞中蛋白质输出的影响
EMBO J. 1984 Oct;3(10):2315-8. doi: 10.1002/j.1460-2075.1984.tb02132.x.

本文引用的文献

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The DNA sequence of the H-2kb gene: evidence for gene conversion as a mechanism for the generation of polymorphism in histocompatibilty antigens.H-2kb基因的DNA序列：基因转换作为组织相容性抗原多态性产生机制的证据。
EMBO J. 1983;2(3):453-62. doi: 10.1002/j.1460-2075.1983.tb01444.x.
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Transfer of proteins across membranes.蛋白质跨膜转运
Annu Rev Biochem. 1981;50:317-48. doi: 10.1146/annurev.bi.50.070181.001533.
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Gene conversion: some implications for immunoglobulin genes.基因转换：对免疫球蛋白基因的一些影响。
Cell. 1981 Jun;24(3):592-4. doi: 10.1016/0092-8674(81)90082-9.
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Evidence for a new segregant series of B cell antigens that are encoded in the HLA-D region and that stimulate secondary allogenic proliferative and cytotoxic responses.存在一系列新的B细胞抗原分离株的证据，这些抗原由HLA - D区域编码，并刺激二次同种异体增殖和细胞毒性反应。
J Exp Med. 1980 Sep 1;152(3):565-80. doi: 10.1084/jem.152.3.565.
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Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: similarities with immunoglobulins and HLA-A, -B, and -C antigens.根据核苷酸序列预测的一种HLA - DR抗原样β链的完整氨基酸序列：与免疫球蛋白以及HLA - A、- B和 - C抗原的相似性。
Proc Natl Acad Sci U S A. 1982 Jun;79(12):3687-91. doi: 10.1073/pnas.79.12.3687.
6
HLA-DR light chain has a polymorphic N-terminal region and a conserved immunoglobulin-like C-terminal region.人类白细胞抗原-DR轻链具有一个多态性的N端区域和一个保守的免疫球蛋白样C端区域。
Nature. 1982 Jun 24;297(5868):694-7. doi: 10.1038/297694a0.
7
A pseudogene homologous to mouse transplantation antigens: transplantation antigens are encoded by eight exons that correlate with protein domains.一个与小鼠移植抗原同源的假基因：移植抗原由与蛋白质结构域相关的八个外显子编码。
Cell. 1981 Sep;25(3):683-92. doi: 10.1016/0092-8674(81)90175-6.
8
Alpha chain of HLA-DR transplantation antigens is a member of the same protein superfamily as the immunoglobulins.HLA - DR移植抗原的α链与免疫球蛋白属于同一蛋白质超家族成员。
Cell. 1982 Aug;30(1):153-61. doi: 10.1016/0092-8674(82)90021-6.
9
Evolution of mouse immunoglobulin lambda genes.小鼠免疫球蛋白λ基因的进化
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4681-5. doi: 10.1073/pnas.79.15.4681.
10
Organization and evolution of immunoglobulin VH gene subgroups.免疫球蛋白VH基因亚群的组织与进化
Proc Natl Acad Sci U S A. 1982 Jul;79(14):4405-9. doi: 10.1073/pnas.79.14.4405.

人类主要组织相容性抗原DCβ基因的外显子-内含子结构及完整核苷酸序列

Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene.

作者信息

Larhammar D, Hyldig-Nielsen J J, Servenius B, Andersson G, Rask L, Peterson P A

出版信息

Proc Natl Acad Sci U S A. 1983 Dec;80(23):7313-7. doi: 10.1073/pnas.80.23.7313.

DOI:10.1073/pnas.80.23.7313
PMID:6316358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC390045/
Abstract

We have determined the complete nucleotide sequence of a human class II histocompatibility antigen DC beta gene. The gene spans more than 7 kilobases and contains five exons corresponding to the different domains of the DC beta polypeptide. The exon-intron organization is thus analogous to that of class II antigen alpha-chain genes, class I antigen heavy chain genes, and the constant parts of immunoglobulin genes, emphasizing further the evolutionary relationship among these molecules. The mature polypeptide deduced from the DC beta gene shows 93% and 88% homology, respectively, to sequences derived from two DC beta cDNA clones of other haplotypes. The allelic polymorphism of DC beta chains resides predominantly in the first extracellular domain, whereas the rest of the polypeptide is virtually constant. The exons of the DC beta gene display high homology to the corresponding exons of a murine I-A beta gene. Also, the introns show significant homology. The DC beta chains lack eight amino acids in the cytoplasmic tail, as compared to DR and I-A beta chains. This is probably due to a nonfunctional splice junction of DC beta genes, causing a separate cytoplasmic exon to be nonexpressed.

摘要

我们已经确定了人类Ⅱ类组织相容性抗原DCβ基因的完整核苷酸序列。该基因跨度超过7千碱基，包含五个外显子，分别对应于DCβ多肽的不同结构域。因此，外显子 - 内含子组织类似于Ⅱ类抗原α链基因、Ⅰ类抗原重链基因和免疫球蛋白基因的恒定区部分，进一步强调了这些分子之间的进化关系。从DCβ基因推导的成熟多肽与来自其他单倍型的两个DCβ cDNA克隆的序列分别显示出93%和88%的同源性。DCβ链的等位基因多态性主要存在于第一个细胞外结构域，而多肽的其余部分实际上是恒定的。DCβ基因的外显子与小鼠I - Aβ基因的相应外显子显示出高度同源性。此外，内含子也显示出显著的同源性。与DR和I - Aβ链相比，DCβ链的胞质尾部缺少八个氨基酸。这可能是由于DCβ基因的一个无功能剪接位点，导致一个单独的胞质外显子不表达。