Hudault S, Bridonneau C, Raibaud P
Ann Microbiol (Paris). 1983 Sep-Oct;134B(2):277-83.
Axenic mice died with signs of enterotoxaemia after oral ingestion of Clostridium perfringens type C or D. Under the same conditions, C. perfringens type B was less pathogenic, and types A and E showed no pathogenicity. The microflora of conventional mice prevented the establishment of C. perfringens types B, C and D in the digestive tract and protected them against the pathogenicity of these strains. Toxins produced in the caecum of monoxenic mice harbouring C. perfringens type C were not neutralized by the anti-C. perfringens type C antiserum. This suggests that the toxins produced in vivo by this strain were different from those produced in vitro.
无菌小鼠经口摄入C型或D型产气荚膜梭菌后，会出现肠毒血症症状而死亡。在相同条件下，B型产气荚膜梭菌致病性较弱，而A型和E型则无致病性。常规小鼠的微生物群可阻止B型、C型和D型产气荚膜梭菌在消化道定殖，并保护它们免受这些菌株致病性的影响。在携带C型产气荚膜梭菌的单菌小鼠盲肠中产生的毒素，不能被抗C型产气荚膜梭菌抗血清中和。这表明该菌株在体内产生的毒素与体外产生的毒素不同。
