γ-氨基丁酸在大鼠吗啡戒断中的作用。

The role of GABA in morphine abstinence in rats.

作者信息

Kruszewska A

机构信息

Department of Pharmacodynamics, Medical Academy, Lublin, Poland.

出版信息

Drug Alcohol Depend. 1988 Feb;21(1):37-41. doi: 10.1016/0376-8716(88)90008-7.

DOI:10.1016/0376-8716(88)90008-7

PMID:3366053

Abstract

GABA mimetics such as baclofen, aminooxyacetic acid (AOAA) and diazepam decreased naloxone-precipitated abstinence wet dog shakes in morphine dependent rats. The GABA antagonists bicuculline and picrotoxin were not effective in small doses. The inhibition of wet dog shakes by baclofen, AOAA and diazepam was not reversed by bicuculline. This suggests that baclofen, AOAA and diazepam may inhibit morphine wet dog shakes not by direct GABA receptor stimulation. Inhibition by baclofen of wet dog shakes was reversed by 5-hydroxytryptophan (5-HTP) suggesting that the inhibiting effects of GABA mimetics are mediated by serotoninergic neurons.

摘要

γ-氨基丁酸（GABA）模拟物，如巴氯芬、氨氧乙酸（AOAA）和地西泮，可减少吗啡依赖大鼠中纳洛酮诱发的戒断性湿狗样抖动。GABA拮抗剂荷包牡丹碱和印防己毒素小剂量时无效。巴氯芬、AOAA和地西泮对湿狗样抖动的抑制作用不会被荷包牡丹碱逆转。这表明巴氯芬、AOAA和地西泮可能不是通过直接刺激GABA受体来抑制吗啡引起的湿狗样抖动。5-羟色氨酸（5-HTP）可逆转巴氯芬对湿狗样抖动的抑制作用，提示GABA模拟物的抑制作用是由5-羟色胺能神经元介导的。