Schmitz O, Rømer F K, Alberti K G, Hreidarsson A B, Orskov H
Diabete Metab. 1983 Sep;9(3):179-82.
Serum angiotensin-converting enzyme (s-ACE) was measured in 56 diabetic outpatients and in 6 juvenile insulin dependent diabetics who developed mild to moderate ketosis after insulin withdrawal. In the outpatients mean s-ACE was increased by 24% compared to healthy controls. However, development of ketosis resulted in significant reduction of s-ACE from 29.2 +/- 1.6 U/ml (+/- SEM) to 23.1 +/- 1.9 U/ml (p less than 0.05). In addition, a clearcut inverse correlation was observed between blood-3-hydroxybutyrate rise and s-ACE decrement (p less than 0.01). The reduction observed may be mediated through the metabolic acidosis.
对56名糖尿病门诊患者以及6名在胰岛素撤药后出现轻至中度酮症的青少年胰岛素依赖型糖尿病患者测定了血清血管紧张素转换酶（s-ACE）。在门诊患者中，与健康对照相比，平均s-ACE升高了24%。然而，酮症的发生导致s-ACE从29.2±1.6 U/ml（±标准误）显著降至23.1±1.9 U/ml（p<0.05）。此外，观察到血液中3-羟基丁酸升高与s-ACE降低之间存在明显的负相关（p<0.01）。观察到的降低可能是通过代谢性酸中毒介导的。
