维生素C刺激人髓过氧化物酶的氯化活性。
Vitamin C stimulates the chlorinating activity of human myeloperoxidase.
作者信息
Bolscher B G, Zoutberg G R, Cuperus R A, Wever R
出版信息
Biochim Biophys Acta. 1984 Jan 31;784(2-3):189-91. doi: 10.1016/0167-4838(84)90127-4.
PMID:6318833
Abstract
Ascorbic acid (vitamin C) was found to stimulate the chlorinating activity of human myeloperoxidase (donor:hydrogen peroxide oxidoreductase, EC 1.11.1.7) 3-fold in vitro and to shift the pH optimum of the reaction to higher pH values. These effects are due to the conversion by ascorbic acid of inactive compound II formed during turnover into native enzyme.
摘要
已发现抗坏血酸（维生素C）在体外可将人髓过氧化物酶（供体：过氧化氢氧化还原酶，EC 1.11.1.7）的氯化活性提高3倍，并使反应的最适pH值向更高pH值移动。这些效应是由于抗坏血酸将周转过程中形成的无活性化合物II转化为天然酶所致。
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