Mason G A, Bissette G, Nemeroff C B
Brain Res. 1983 Dec 19;289(1-2):366-9. doi: 10.1016/0006-8993(83)90044-6.
The acute effects of administration of 4 excitatory amino acids (n-methyl-DL-aspartic acid (NMA), kainic acid (KA), ibotenic acid (IA) and quinolinic acid (QA] on the serum concentrations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), growth hormone (GH) and prolactin (PRL) were studied in the rat. NMA-treated rats exhibited increased serum LH and GH concentrations while KA-treated rats-showed increases only in serum GH concentrations. Neither IA nor QA altered adenohypophyseal hormone levels. These endocrine alterations induced by NMA and KA are different from those previously reported after administration of glutamate, another excitatory amino acid. The finding that all of the excitatory amino acids studied did not produce identical effects on anterior pituitary hormone secretion may be due to differential permeability of these substances into the central nervous system or because they act at different subtypes of excitatory amino acid receptors.
研究了给大鼠注射4种兴奋性氨基酸（N-甲基-DL-天冬氨酸（NMA）、 kainic酸（KA）、鹅膏蕈氨酸（IA）和喹啉酸（QA））对血清促黄体生成素（LH）、促卵泡激素（FSH）、生长激素（GH）和催乳素（PRL）浓度的急性影响。经NMA处理的大鼠血清LH和GH浓度升高，而经KA处理的大鼠仅血清GH浓度升高。IA和QA均未改变腺垂体激素水平。NMA和KA诱导的这些内分泌改变与先前报道的另一种兴奋性氨基酸谷氨酸给药后的改变不同。所研究的所有兴奋性氨基酸对垂体前叶激素分泌未产生相同影响，这一发现可能是由于这些物质进入中枢神经系统的通透性不同，或者是因为它们作用于兴奋性氨基酸受体的不同亚型。
