Hoshino T, Matsumori A, Kawai C, Imai J
Cardiovasc Res. 1984 Jan;18(1):24-9. doi: 10.1093/cvr/18.1.24.
We inoculated Coxsackie virus B1 (CVB1) intraperitoneally into 36 2-week-old Syrian golden hamsters. Serial ECGs were recorded from 10 hamsters which survived the acute and electrocardiographically manifest myocarditis. In a mean 17.8 week (range 9 to 31 weeks) follow-up period, chronic ventricular premature contractions (VPC) followed the acute ECG changes in three of the animals. VPC were recorded in a uniform contour in a hamsters, which had a ventricular aneurysm and were of two kinds of contour in the other two hamsters, each of which had two ventricular aneurysms. No VPC was recorded from the other seven hamsters, which had no aneurysms in the heart. None of the inoculated animals died during the follow-up period, irrespective of the existence of ventricular aneurysm, after surviving the first 2 weeks post-infection. The results demonstrate a close relationship between chronic VPC of uniform contours following CVB1 myocarditis and the formation of ventricular aneurysms in Syrian golden hamsters. The hamsters were able to live for a considerably long period with the aneurysms. Ventricular aneurysms following CVB1 myocarditis in Syrian golden hamsters may be an experimental model of human ventricular aneurysms of unknown etiology.
我们将柯萨奇病毒B1（CVB1）经腹腔接种到36只2周龄的叙利亚金黄地鼠体内。对10只在急性期存活且心电图显示有心肌炎的地鼠进行了系列心电图记录。在平均17.8周（范围9至31周）的随访期内，三只动物在急性心电图改变后出现了慢性室性早搏（VPC）。一只患有心室瘤的地鼠记录到的VPC形态一致，另外两只各有两个心室瘤的地鼠记录到的VPC有两种形态。另外七只心脏无动脉瘤的地鼠未记录到VPC。在感染后存活的前两周后，无论是否存在心室瘤，所有接种的动物在随访期间均未死亡。结果表明，CVB1心肌炎后形态一致的慢性VPC与叙利亚金黄地鼠心室瘤的形成密切相关。这些地鼠能够带着动脉瘤存活相当长的时间。叙利亚金黄地鼠CVB1心肌炎后的心室瘤可能是人类病因不明的心室瘤的实验模型。
